Lsd amnesia weed1/1/2024 The most common psychoactive drug precipitant of the disorder is cannabis ( 3, 5). Several precipitants have been implicated in depersonalization-derealization disorder, including panic attacks ( 3) and recreational drugs ( 5). Personality disorders do not appear to predict symptom severity ( 8). However, it is uncommon for an individual with depersonalization-derealization disorder to have schizotypal or schizoid personality disorder ( 8). Persons with the disorder may present with comorbid psychiatric disorders, including personality disorders ( 8). The average age at onset is 16 years ( 8), and women and men are equally affected ( 5). ![]() The lifetime prevalence of depersonalization-derealization disorder is approximately 2% both in the United States and worldwide ( 4). Persons with depersonalization-derealization do not appear to be at risk for developing psychotic disorders ( 2, 3). Whereas an individual with schizophrenia may believe that he or she is actually outside of his or her body, persons with depersonalization-derealization are aware that the dissociation is merely an uncanny sensation ( 5). However, persons with depersonalization-derealization are distinguished from those with psychotic disorders by the presence of intact reality testing regarding the dissociative disturbance ( 4). Transient episodes of depersonalization or derealization have been known to occur across a broad range of psychiatric disorders, including schizophrenia ( 7). Both symptoms may be a cause of significant distress and functional impairment ( 4– 6). Derealization is marked by feelings of unreality and detachment from one's surroundings ( 4), such that one's environment is experienced as remote or unfamiliar ( 5). Depersonalization is a dissociative symptom in which one feels like an outside observer with respect to one's thoughts, body, and sensations ( 3). The principal clinical features of depersonalization-derealization disorder are persistent or recurrent experiences of depersonalization or derealization ( 4). Moreover, there is a dearth of literature on the clinical characteristics of and risk factors for depersonalization-derealization disorder as precipitated by cannabis use ( 3). However, little is known about how cannabis use relates to other psychiatric sequelae ( 2). ![]() An association between cannabis use and the emergence of psychotic disorders among susceptible individuals is increasingly being described in the medical literature ( 1).
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